The perfect metaphor for the pharmaceutical industry and the state of modern medicine.
>An Oxford review examining 37 studies involving more than 9,300 people found that on average, users gained around a pound a month after quitting.
Yes, because, as ever, big pharma is only interested in treating the $ymptom not the condition.
OwlsAboutThatThen on
Surely the GLP1 debate actually proves one thing.
That for many, weight gain is hormonal, not a willpower issue.
Background-Flight323 on
I’d have thought that restricting food intake for a reasonable amount of time would change patients’ habits. The fact that it apparently doesn’t suggests we still don’t understand (or are unable to treat) the root cause of obesity, only the symptoms.
Dapper-Confusion5832 on
I’ve been reading an interesting book over Christmas called “Ultra processed people”. It talks about how modern obesity is not due to fats, or carbs, but actually ultra processing of our modern diets. The ultra processing tricks our brains into over consumption, and allows us to consume quantities of sugar that we would never tolerate otherwise (try eating 30g of sugar in tablespoons). Ultra processed foods also have addictive like qualities, and some people do have genetic components where their brains don’t tell them to stop. The drug is a fix for the symptoms of the current food industry, but the food itself is the problem that needs fixing.
[deleted] on
[deleted]
Deadliftdeadlife on
Very lucky to have used these drugs and it completely changed my eating habits and I didn’t gain weight back after coming off them
It’s a shame it can’t be that way for everyone
Edit : here’s what I think is going to happen to a lot of people
These drugs cause extreme calorie deficits
Big deficits without exercise, mainly resistance training, cause a large % of muscle to be lost as weight
So people lose lots of muscle and fat, making them less metabolically active.
They cone off the drugs and gain the weight back
The cycle repeats
Sonchay on
It must be remembered that the currently approved drugs still represent an early generation of these medicines and a considerable amount of investment has gone into development of successors. There are about a dozen follow-up candidates in clinical development that are aiming to address the issues of rebound weight gain and also to try and focus the weight loss more specifically on fat. So I would take care about getting too outraged when reading articles about how “awfully wobbly” these Wright Brothers planes are.
pitiless on
Chronic medical conditions require ongoing medication – I keep seeing articles saying basically this and it’s really annoying. I’ve got multiple chronic health issues that require that I take medication for the rest of my life – I cannot see the difference between my kidney medication and this.
Imagine the same headline, but the topic is type one diabetics and insulin. Absolutely absurd article.
speedloafer on
“Fat jabs” Typical UK and from a news source too. Although “News” is being generous.
Spare_Worldliness669 on
They provide an instant ability for people who previously struggled to manage a calorie deficit. Although that already varies for some. I’m happy to say I’m on Wegovy. I had a much lower starting BMI than some who use it but the effects on my sleep, my back and my ability to be the active parent I want to be were clear.
I’ve lost about 15KG (about 2 stone 3lbs) since I started about 80 days ago. But actually the biggest changes I’ve achieved have been lifestyle and eating habits. One’s I’ve made before but without the meds but this time as part of a more sustainable look at life. Before the diets were based around eating what this or that diet said I should. No carbs, lots of soup, this fad or that. This time I’m actually looking at changing how I eat not always what. Understanding that you can eat carbs and chocolate and still lose weight if you factor them in makes the diet more sustainable as you’re not depriving yourself of things you enjoy. A glass of wine on a Friday is fine if you count it.
Treats such as a nice meal out rather than a lazy pizza in the oven, finding high protein diets that scratch that itch. Finding the joy in exercise again.
It’s been more like a reset than taking something that makes me not eat at all. I still feel hunger and still have cravings for custard creams (others don’t, but my response has been more mild). I actually think there’s something to be said for staying on the lowest possible dose that means you still need to think about what and how you’re eating so it is exercising people’s will power still, not just making it so people don’t have to think about what they are eating because they can’t eat much.
I think the medication is excellent but it needs to stop being viewed as a magic fat burning jab and looked at far more holistically, as part of a bigger thing. I hope I’m managing to do this but it shouldn’t be something left or the individual to build in otherwise the journey won’t be sustainable and the chance of bouncing back quickly is really possible.
ByronsLastStand on
Most people need to make lifestyle changes alongside any assistance from ozempic and similar substances. Learning to cook from scratch, portion control, cutting down on processed sugar, and some form of regular exercise (doesn’t have to by the gym).
Declanmar on
Why is this shocking to people? Generally medications stop working when you don’t take them.
Ok_Promotion3591 on
People want a shitty ultra processed diet more than they want a healthy body. I do a lot of exercise each week and when I go shopping, do I see those jam doughnuts, pringles and Toblerone bars, and feel a craving to eat them? Yes. Do I buy them? No.
shytalk on
“Calorie control and regular exercise may need to be taken for life, health experts warn”
takesthebiscuit on
Nonsense, they will soon launch a tablet form.
Now they will be taken for life!
Traffodil on
The title is misleading. “GLP-1 agonists may need to be taken…” is more accurate but it’s very possible a better hormone may be found to target in the future. We’re in the very early stages of this type of treatment. I have no doubt that in the near future ’fat jabs’ will be replaced by tablets, patches or such like.
DigbyGibbers on
Unsurprising really, it’s a chronic condition.
They seem to have a study in rats that has demonstrated a gene therapy that causes the pancreas to release GLP-1, I’m not sure it’s something that I’d be keen on though. Currently the oral versions that are showing good results are what I expect to take over the long term.
Overall I’m just thankful they developed a treatment.
Doobreh on
until they become pills, as one already has. These headlines are so poorly written.
LilaTwiceBackAtIt on
Idk how people can argue that this is normal or healthy. Unless you have diabetes or a diagnosed illness, surely there are better ways to overcome your weight problems than paying £300 a month to inject something into your stomach that blocks your appetite. It’s almost dystopian. The amount of people taking this is wild. Rather than just work on mental health, exercise, healthy eating.
Oldschool-fool on
Can’t believe how many people are on these when no one really knows the long term effects 😵💫
20 Comments
The perfect metaphor for the pharmaceutical industry and the state of modern medicine.
>An Oxford review examining 37 studies involving more than 9,300 people found that on average, users gained around a pound a month after quitting.
Yes, because, as ever, big pharma is only interested in treating the $ymptom not the condition.
Surely the GLP1 debate actually proves one thing.
That for many, weight gain is hormonal, not a willpower issue.
I’d have thought that restricting food intake for a reasonable amount of time would change patients’ habits. The fact that it apparently doesn’t suggests we still don’t understand (or are unable to treat) the root cause of obesity, only the symptoms.
I’ve been reading an interesting book over Christmas called “Ultra processed people”. It talks about how modern obesity is not due to fats, or carbs, but actually ultra processing of our modern diets. The ultra processing tricks our brains into over consumption, and allows us to consume quantities of sugar that we would never tolerate otherwise (try eating 30g of sugar in tablespoons). Ultra processed foods also have addictive like qualities, and some people do have genetic components where their brains don’t tell them to stop. The drug is a fix for the symptoms of the current food industry, but the food itself is the problem that needs fixing.
[deleted]
Very lucky to have used these drugs and it completely changed my eating habits and I didn’t gain weight back after coming off them
It’s a shame it can’t be that way for everyone
Edit : here’s what I think is going to happen to a lot of people
These drugs cause extreme calorie deficits
Big deficits without exercise, mainly resistance training, cause a large % of muscle to be lost as weight
So people lose lots of muscle and fat, making them less metabolically active.
They cone off the drugs and gain the weight back
The cycle repeats
It must be remembered that the currently approved drugs still represent an early generation of these medicines and a considerable amount of investment has gone into development of successors. There are about a dozen follow-up candidates in clinical development that are aiming to address the issues of rebound weight gain and also to try and focus the weight loss more specifically on fat. So I would take care about getting too outraged when reading articles about how “awfully wobbly” these Wright Brothers planes are.
Chronic medical conditions require ongoing medication – I keep seeing articles saying basically this and it’s really annoying. I’ve got multiple chronic health issues that require that I take medication for the rest of my life – I cannot see the difference between my kidney medication and this.
Imagine the same headline, but the topic is type one diabetics and insulin. Absolutely absurd article.
“Fat jabs” Typical UK and from a news source too. Although “News” is being generous.
They provide an instant ability for people who previously struggled to manage a calorie deficit. Although that already varies for some. I’m happy to say I’m on Wegovy. I had a much lower starting BMI than some who use it but the effects on my sleep, my back and my ability to be the active parent I want to be were clear.
I’ve lost about 15KG (about 2 stone 3lbs) since I started about 80 days ago. But actually the biggest changes I’ve achieved have been lifestyle and eating habits. One’s I’ve made before but without the meds but this time as part of a more sustainable look at life. Before the diets were based around eating what this or that diet said I should. No carbs, lots of soup, this fad or that. This time I’m actually looking at changing how I eat not always what. Understanding that you can eat carbs and chocolate and still lose weight if you factor them in makes the diet more sustainable as you’re not depriving yourself of things you enjoy. A glass of wine on a Friday is fine if you count it.
Treats such as a nice meal out rather than a lazy pizza in the oven, finding high protein diets that scratch that itch. Finding the joy in exercise again.
It’s been more like a reset than taking something that makes me not eat at all. I still feel hunger and still have cravings for custard creams (others don’t, but my response has been more mild). I actually think there’s something to be said for staying on the lowest possible dose that means you still need to think about what and how you’re eating so it is exercising people’s will power still, not just making it so people don’t have to think about what they are eating because they can’t eat much.
I think the medication is excellent but it needs to stop being viewed as a magic fat burning jab and looked at far more holistically, as part of a bigger thing. I hope I’m managing to do this but it shouldn’t be something left or the individual to build in otherwise the journey won’t be sustainable and the chance of bouncing back quickly is really possible.
Most people need to make lifestyle changes alongside any assistance from ozempic and similar substances. Learning to cook from scratch, portion control, cutting down on processed sugar, and some form of regular exercise (doesn’t have to by the gym).
Why is this shocking to people? Generally medications stop working when you don’t take them.
People want a shitty ultra processed diet more than they want a healthy body. I do a lot of exercise each week and when I go shopping, do I see those jam doughnuts, pringles and Toblerone bars, and feel a craving to eat them? Yes. Do I buy them? No.
“Calorie control and regular exercise may need to be taken for life, health experts warn”
Nonsense, they will soon launch a tablet form.
Now they will be taken for life!
The title is misleading. “GLP-1 agonists may need to be taken…” is more accurate but it’s very possible a better hormone may be found to target in the future. We’re in the very early stages of this type of treatment. I have no doubt that in the near future ’fat jabs’ will be replaced by tablets, patches or such like.
Unsurprising really, it’s a chronic condition.
They seem to have a study in rats that has demonstrated a gene therapy that causes the pancreas to release GLP-1, I’m not sure it’s something that I’d be keen on though. Currently the oral versions that are showing good results are what I expect to take over the long term.
Overall I’m just thankful they developed a treatment.
until they become pills, as one already has. These headlines are so poorly written.
Idk how people can argue that this is normal or healthy. Unless you have diabetes or a diagnosed illness, surely there are better ways to overcome your weight problems than paying £300 a month to inject something into your stomach that blocks your appetite. It’s almost dystopian. The amount of people taking this is wild. Rather than just work on mental health, exercise, healthy eating.
Can’t believe how many people are on these when no one really knows the long term effects 😵💫